Fecal virome transplantation attenuates arthritis in mice by remodeling gut ecology, systemic tryptophan metabolism, and innate immune responses.

Akkermansia abundance showed a moderate negative trend with arthritis clinical scores ( r = −0.57, p = 0.09), although this did not reach statistical significance (Supplementary Fig. 3A ).

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At the individual metabolite level, circulating L-tryptophan levels showed a decreasing trend in arthritic mice and a partial recovery following VLP treatment (Fig. 8C ).

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