GWAS on short tandem repeats identifies genetic mechanisms in Alzheimer's disease.

Nat Commun · 2026 · PMC13237113 · PMID 42243151

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hedged sentences

0.0000

closest p · 0.0× alpha

0.0093

boldest claim

The sentences

highly significantP < 2.2E−308actually significant

22A ) and revealed a highly significant correlation of effect sizes (Spearman’s rank correlation) between both types of variants ( r = 0.85, P < 2.2E−308).

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nominally significantP = 9.33E−03actually significant

A similar situation was encountered in APOE , where one STR (chr19:44910674) showed a change in P value from merely nominally significant ( P = 9.33E−03) to genome-wide significant ( P = 4.67E−23) (Supplementary Data 10 ) after conditioning on rs429358 (“e4-allele” in APOE ).

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