SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity.

In a separate 8-day proliferation assay, all missense mutants exhibited impaired antiproliferative function: W281P achieved 27.4% ± 4.2% (mean ± SD) growth suppression, E300K achieved 49.8% ± 6.9%, and I315R achieved 6.4% ± 17.6%, while D277K showed 42.4% ± 9.4% growth suppression that did not reach statistical significance (Fig. 2i ).

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