DMN function changes on resting state fMRI in perimenopausal women.

Open Med (Wars) · 2026 · PMC13238467 · PMID 42254985

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.0750

boldest claim

The sentences

marginally significantp=0.058so close (0.05 < p ≤ 0.1)

Exploratory analyses showed marginally significant positive associations between E2 decline magnitude and right MFG/PCC connectivity (r=0.376–0.402, p=0.058–0.075), interpreted as preliminary trends.

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showed a trendp=0.075so close (0.05 < p ≤ 0.1)

Our supplementary analyses showed a trend toward positive correlation between E2 decline and PCC compensation (r=0.376, p=0.075), indicating the PCC prioritizes compensation to preserve memory function amid E2 loss.

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