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Efficacy of Antipsychotic Augmentation Therapy in Treatment-Resistant Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis.

Cureus · 2026 · PMC13238950 · PMID 42255829

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The effects of quetiapine (SMD = -0.21; 95% CI: -1.04 to 0.63, six studies) and risperidone (SMD = -0.49; 95% CI: -1.25 to 0.28, three studies) failed to reach statistical significance when pooled against placebo, though considerable within-group heterogeneity was noted (Figure 6 ).

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