Distinct UNC13A Haplotype Blocks Define Disease Severity and Survival in Chinese Amyotrophic Lateral Sclerosis.

When conditioning on the rs75421007 (Block 1) GG genotype background, the survival association of rs78549703 (Block 2) remained highly significant under both additive (Cox HR = 1.61, 95% CI: 1.11–2.33, p = 0.011) and recessive models (Cox HR = 1.59, 95% CI: 1.10–2.28, p = 0.013).

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Similarly, when conditioned on the rs12608932 genotype, the association of rs12973192 was attenuated and did not reach statistical significance (genotypic p = 0.12; recessive p = 0.076) (Figure S3 ).

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