Dissecting the polygenic architecture of psychopathology via singular value decomposition of eight psychiatric genome-wide association studies and evaluation of component-based polygenic scores.

Using a 25% cumulative variance threshold, 38 of the 55 gene sets enriched at FDR < 0.05 under the 50% threshold remained nominally significant ( p value < 0.05), indicating that the primary biological signals were largely preserved.

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