Neural Correlates of Virtual Reality Intervention in Children With Attention-Deficit/Hyperactivity Disorder: A Resting-State fMRI Study Based on Percent Amplitude of Fluctuation.

The main findings can be summarized as follows: VR intervention was associated with significant improvements in hyperactivity/impulsivity and oppositional behaviors; following intervention, neural activity in the right MFG, a region implicated in cognitive control, showed a trend toward normalization, as reflected by decreased PerAF values, while activity in the left PCL, associated with sensorimotor integration, was increased; improvements in inattention were relatively limited, and elevated activity in the left ITG persisted after intervention and was positively correlated with oppositional defiant symptoms.

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