Deep Phenotyping of F64L Mutation in a Multicentric Cohort of Patisiran-Treated Hereditary Transthyretin Amyloidosis Patients (Patisiranitaly).

Eur J Neurol · 2026 · PMC13240185 · PMID 42226514

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp < 0.001actually significant

This distribution was highly significant (χ 2 = 135.0, df = 1, p < 0.001).

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did not reach statistical significanceno p-value reported

Cardiac onset was less frequent in F64L (−2.8) compared with non‐F64L (+1.9); moreover, neurologic onset was more frequent in F64L (+1.9) and less common in non‐F64L (−1.3), although these last differences did not reach statistical significance.

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