Multiomics insights into the effects of prebiotics on physical function and metabolism in adults with obesity and knee osteoarthritis.

While no significant changes were observed in other enzymatic activities, β - N -acetylglucosaminidase, which hydrolyzes the β -1,4 or β -1,3 bonds between N -acetylglucosamine residues in host glycans and glycosaminoglycans, showed a trend of lower activity in the prebiotic group at month 6 ( p = 0.0518, Figure 4B , Table S12).

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At the genus level, specialist genus Akkermansia showed an increasing trend in the placebo group from month 3 to 6 ( p = 0.0556) and a higher abundance in the placebo group at month 6 ( p = 0.0649, Figure 5D-E ).

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