Intracranial Arterial Calcification on Computed Tomography and Risk of Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis.

Cerebrovasc Dis · 2026 · PMC13241076 · PMID 41984754

Europe PMC DOI

hedged sentences

0.2900

closest p · 5.8× alpha

0.3600

boldest claim

The sentences

did not reach statistical significancep = 0.29not close (p > 0.1)

Regarding cross-sectional studies reporting severity measures, meta-analysis suggested higher odds of cognitive impairment among individuals with high CT-IAC, although the association did not reach statistical significance (pooled aOR = 2.29, 0.50–10.57, p = 0.29; Fig. 3 ).

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a weak trendp = 0.36not close (p > 0.1)

bottom tertile of medial/IEL ICA CT-IAC predicted dementia on pooled analysis (aOR = 2.35, 1.29–4.28, p = 0.005), whereas there was only a weak trend for the atherosclerotic intimal subtype (aOR = 1.29, 0.75–2.23, p = 0.36).

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