Multi-omics and experimental evidence in human chondrocytes identify caspase-8 as a non-apoptotic regulator of inflammatory, senescent, and fibrotic signaling in osteoarthritis.

Cell Commun Signal · 2026 · PMC13242140 · PMID 42249421

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did not reach statistical significanceno p-value reported

Although additional instruments and HOA estimates did not reach statistical significance, they pointed in the same risk-increasing direction.

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