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Allogeneic CD19 CAR T cells armed with an anti-rejection CD70 CAR overcome antigen escape and evade alloimmune responses.

Nat Commun · 2026 · PMC13243484 · PMID 41965340

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In vivo, CD8/CD28-HTM CAR T cells showed a slight reduction in efficacy compared to CD8/CD8-HTM CAR T cells for two of the three donors tested, although these differences did not reach statistical significance.

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