Identification of biomarkers in myocardial hypertrophy and fibrosis via integrated transcriptomic and phosphoproteomic profiling.

PRRX1 exhibited one highly significant correlation with TMEM33 ( r = − 1.000, p = 0.0028), while SLAIN2 showed significant positive correlations with PTPN2 ( r = 0.886, p = 0.033) and TMEM33 ( r = 0.943, p = 0.017).

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In contrast, CLIP2 ( p = 0.75) and PLA2G4A ( p = 0.16) did not reach statistical significance in cardiomyocytes alone, though their expression trends were consistent with bulk tissue patterns.

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