Sleep interruption aggravates sepsis by rewiring the macrophage immune response.

Although there was a slight trend toward higher disease scores at 24 to 60 hours, this difference was not significant and resolved by 72 hours ( Fig. 3C ).

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This effect was observed within every group (normal sleep, sleep interruption, and control procedure), and all were significant except for neutrophils in the normal sleep group, which still showed a strong trend.

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