Chronic High-Fat Diet Does Not Alter Overall Cancer Incidence in Trp53R270H/+ Mice.

Cancer Res Commun · 2026 · PMC13244378 · PMID 42165629

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hedged sentences

0.0630

closest p · 1.3× alpha

0.0630

boldest claim

The sentences

a nonsignificant trendP = 0.063so close (0.05 < p ≤ 0.1)

The only exception was a nonsignificant trend in carcinoma-specific survival in females ( P = 0.063; Supplementary Fig.

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showed a trendno p-value reported

Second, ddPCR analysis showed a trend toward an increased mutant-to-WT ratio for the Trp53 alleles in lung tumor relative to contralateral normal tissue from HFD-fed animals, suggesting a potential loss-of-heterozygosity (LOH) event at this locus under HFD conditions (Supplementary Fig.

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