Left atrial appendage exclusion during open cardiac surgery in patients without atrial fibrillation reduces 4-year ischemic stroke and mortality.

In patients with LAAE + OAC use compared with No-LAAE + OAC the differences in adjusted ischemic stroke through 4 years did not reach statistical significance (9.5% vs 14.1%; P = .17) ( Figure 3 ), although a 64% reduction in odds of ischemic stroke was present in late follow-up for LAAE + OAC (31 days to 4 years) (4.6% vs 11.7%; P < .00).

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