Daily functional impairment shows a significant mediation trend in the frailty–cognition association, and this effect only reaches marginal significance after controlling for chronic disease burden and lifestyle factors.
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A study on the correlation between frailty, sleep quality, and cognitive function in low-income older adults living in the urban-rural fringe of China.
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The sleep–depression–cognition pathway did not reach statistical significance.
Three main findings were obtained: firstly, there was a significant correlation between frailty and cognitive function, with the frailty group having an average MoCA score about 4 points lower than the robust group; Secondly, poor sleep quality, especially prolonged sleep latency, independently predicted lower cognitive scores across all regression models; Thirdly, ADL showed a significant mediation effect in the frailty–cognition association, but after controlling for lifestyle and comorbidity covariates, ADL functional impairment showed only a marginally significant mediation trend in the frailty–cognition association, The mediating pathway of sleep–depression–cognition was not statistically supported.