Association of the -4719A/T Polymorphism in the RAD51 Gene with Demographic and Clinicopathological Features of Lung Cancer in Iraqi Patients.

Furthermore, a highly significant association was found between the presence of the T allele and increased risk of lung cancer (p = 0.00000001), and the results are shown in Table 2 and Figure 1 .

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Nonetheless, the T allele and A/T genotype appeared more frequently among patients with NSCLC than SCLC, those with advanced tumor stage (stage IV), higher tumor grade (grade III), and those with lymph node metastases, although these differences did not reach statistical significance (p = 0.55, 0.3, 0.067, and 0.73, respectively) ( Table 3 ).

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Additionally, although not statistically significant, a higher frequency of the T allele and AT/TT genotypes was observed among smokers compared to non-smokers, indicating a possible trend that warrants further investigation in larger cohorts.

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