Mitochondria limit coenzyme Q export under cholesterol biosynthetic stress.

J Cell Biol · 2026 · PMC13245278 · PMID 42257675

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Quantitative analysis of CoQ partitioning demonstrated that inhibition of the SCAP–SREBP pathway led to a significant decrease in non-mitochondrial CoQ, while the levels of mitochondrial CoQ showed a trend toward an increase ( Fig. 3, j and k ).

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