Peripheral blood circMAN1A2 as a novel diagnostic biomarker for gout: integrated transcriptomic analysis and clinical validation.

Front Mol Biosci · 2026 · PMC13246395 · PMID 42273075

Europe PMC DOI

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closest p · 1.0× alpha

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did not reach statistical significanceP > 0.05actually significant

In contrast, low-density lipoprotein, cholesterol, and triglycerides tended to be negatively correlated with MAN1A2 expression, although these associations did not reach statistical significance ( P > 0.05).

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a decreasing trendno p-value reported

Results Peripheral blood circMAN1A2 levels were significantly lower in patients with gout than in healthy controls, and showed a decreasing trend compared with individuals with HUA. circMAN1A2 showed preliminary diagnostic potential for gout (AUC = 0.86; 95% CI 0.66–1.00), with 90.0% sensitivity and 90.1% specificity.

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