A multifactorial intervertebral disc degeneration model: Integrating inflammation, structural disruption, biomechanical parameters, and neural sensitization.

Bioeng Transl Med · 2026 · PMC13247399 · PMID 42272977

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showed a trendno p-value reported

The inflammatory markers IL6, IL8, and IL1β showed a trend of upregulation in the cytokine group and downregulation in the enzyme group, while the combination group remained close to the control (Figure 6e ).

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