Pharmacological effects of <i>Salvia miltiorrhiza-</i>derived interventions on osteoporosis in animal models: a systematic review and meta-analysis.

miltiorrhiza slightly increased serum E2 levels (SMD = 0.37, 95% CI = −0.15 to 0.88, p = 0.16), but this effect did not reach statistical significance, indicating that its influence on estrogen-related metabolism in OP may be limited; S. miltiorrhiza significantly reduced TRACP levels (SMD = −2.32, 95% CI = −4.01 to −0.64, p = 0.007), indicating its ability to inhibit osteoclast activity and reduce bone resorption; At the same time, it significantly reduced ALP levels (SMD = −1.71, 95% CI = −2.67 to −0.75, p = 0.0005), which may reflect modulation of bone turnover.

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