Endogenously generated Dutch-type Aβ non-fibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation.

A decline in the number of synaptic vesicles was found in the reserve pool beyond 300 nm from the active zone of Dutch compared to wild‐type mice but did not reach statistical significance and appeared to be driven by vesicles in large synapses (Figure S7D and H ).

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