15-PGDH inhibition promotes muscle repair and strength recovery during GLP-1 receptor agonist-induced weight loss.

Notably, despite the reduction in muscle mass, semaglutide alone did not reduce maximal tetanic force and showed a nonsignificant trend toward increased specific force relative to vehicle-treated controls.

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We found that semaglutide, either alone or together with PGDHi, showed a trend toward increased specific force ( Fig. 1 J ), in agreement with the observed preservation of absolute force ( Fig. 1 I ), but a reduced muscle mass.

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