Inhibition of iNOS reduced cerebral vasoconstriction from chronic cocaine and enhanced angiogenesis in the prefrontal cortex.

Brain Res Bull · 2025 · PMC13250813 · PMID 40749958

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VEGF levels were significantly elevated in iNOS-KO (84.04 ± 0.9252 %) mice compared to saline controls (39.26 ± 16.04 %) (P* = 0.026) and showed a trend toward further increase compared to cocaine-WT mice (54.01 ± 2.089 %) (P* = 0.05).

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