Th1/Th17-linked transcription factors TBX21 and RORC were associated with clinical response to rituximab in treatment-resistant schizophrenia.

Brain Behav Immun Health · 2026 · PMC13251702 · PMID 42281898

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However, TBX21 expression showed a trend toward a greater decrease among responders, with a median ΔTBX21 of −0.62 (range −1.06 – 0.00) compared with 0.04 (range −0.75 – 1.37) in non-responders (Mann–Whitney U, p = 0.089). 3.4 Sensitivity analyses In a sensitivity analysis, we repeated the baseline biomarker comparisons within the schizophrenia subgroup only, comparing responders (n = 6) and non-responders (n = 2).

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