Polyelectrolyte nanoparticles enable intracellular delivery of STING protein fragments for ovarian cancer immunotherapy.

STINGΔTM-loaded nanoparticle consistently improved survival compared to nanoparticles loaded with STINGΔTM S365A control providing evidence that on-target STINGΔTM interactions with IRF3 and the resulting cytokine response are responsible for therapeutic benefit, although these effects did not reach statistical significance (p = 0.055 by Log-Rank test, Fig. 6 E).

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