CheckDyn: a multi-cohort computational framework for profiling treatment-induced immune checkpoint dynamics and predicting adaptive resistance to immune checkpoint blockade.

Front Immunol · 2026 · PMC13253502 · PMID 42292485

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approached significanceno p-value reported

Volcano plot analysis across all patients identified TOX2 (log 2 FC = 0.605, −log 10 (padj) = 2.57) and PDCD1 (log 2 FC = 0.810, −log 10 (padj) = 2.59) as reaching both the fold-change (|log 2 FC| > 0.3) and significance (padj < 0.05) thresholds; CD274, LAG3, and IDO1 also approached significance ( Figure 2b ).

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