Predicting ordinal clinical outcomes in at-risk mental states: a multimodal approach.

Front Psychiatry · 2026 · PMC13253625 · PMID 42290980

Europe PMC DOI

hedged sentences

0.0630

closest p · 1.3× alpha

0.0990

boldest claim

The sentences

a trend toward significancep = 0.063so close (0.05 < p ≤ 0.1)

First, the ordinal logistic regression analysis restricted to drug-naïve individuals demonstrated that higher baseline Unusual Thought Content severity (OR = 1.79, 95% CI: 1.29–2.50, p = 0.00058) and higher SCoRS scores (OR = 1.33, 95% CI: 1.03–1.70, p = 0.026) remained significantly associated with worse clinical outcomes, while smaller dMMN amplitude showed a trend toward significance (OR = 0.80, 95% CI: 0.64–1.01, p = 0.063).

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showed a trendp = 0.063so close (0.05 < p ≤ 0.1)

First, the ordinal logistic regression analysis restricted to drug-naïve individuals demonstrated that higher baseline Unusual Thought Content severity (OR = 1.79, 95% CI: 1.29–2.50, p = 0.00058) and higher SCoRS scores (OR = 1.33, 95% CI: 1.03–1.70, p = 0.026) remained significantly associated with worse clinical outcomes, while smaller dMMN amplitude showed a trend toward significance (OR = 0.80, 95% CI: 0.64–1.01, p = 0.063).

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did not reach statistical significancep = 0.099so close (0.05 < p ≤ 0.1)

Although fMMN and dMMN latencies met the majority-rule criterion and were included in the final regression model, their coefficients did not reach statistical significance in the pooled analysis (p = 0.099 and p = 0.145, respectively).

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