Pan-cancer analysis and experimental validation identify CYP19A1 as a prognostic biomarker and oncogenic driver associated with tumor immune microenvironment regulation in gastrointestinal cancers.

Differential expression results were deemed significant if |log2FC| was at least 1 and FDR was below 0.05; results with p-values under 0.05 but FDR of 0.05 or higher were labeled as ‘nominally significant (exploratory)’ and treated with caution.

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Statistical analysis All statistical analyses were performed using R software (version 4.2.1, R Studio), with atwo-tailed p < 0.05 definedasstatistically significant and p < 0.01 as highly significant.

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