Noncanonical Transcription and Splicing Shape the Colorectal Cancer Immunopeptidome in MSI and MSS Tumors.

Mol Cell Proteomics · 2026 · PMC13254395 · PMID 42106149

Europe PMC DOI

hedged sentence

0.1300

closest p · 2.6× alpha

0.1300

boldest claim

The sentences

did not reach statistical significancep = 0.13not close (p > 0.1)

However, these differences did not reach statistical significance by Welch’s t tests ( p = 0.13 for counts; p = 0.20 for TSA/MAP) or Mann–Whitney U tests ( p ≥ 0.35), indicating that, within the limits of this cohort, MSS and MSI-H tumors harbor broadly comparable numbers of noncanonical antigens at the individual tumor level.

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