Vulnerability of the locus coeruleus-entorhinal cortex white matter tract in autosomal dominant Alzheimer's disease.

Alzheimers Dement · 2026 · PMC13254689 · PMID 42273784

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hedged sentences

0.0790

closest p · 1.6× alpha

0.0790

boldest claim

The sentences

did not reach statistical significancep = 0.079so close (0.05 < p ≤ 0.1)

Segmented regression identified a potential breakpoint at age 31 (95% CI 28.8‐33.4) for the LC‐EC tract logFC metric, although this did not reach statistical significance (Davies test p = 0.079; Sup Figure S2 ), likely reflecting our limited sample size.

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approached but did not reach significanceno p-value reported

Pairwise comparisons showed that impaired carriers had significantly lower LC‐EC tract logFC than non‐carriers (logFC: β = 0.067, t (60) = 2.52, p Tukey = 0.037), while the difference between impaired and unimpaired carriers approached but did not reach significance (logFC: β = 0.064, t (60) = 2.31, p Tukey = 0.060).

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