The SMAC-mimetic xevinapant differentially enhances cisplatin and immune checkpoint blockade efficacy in high-risk HPV-positive tumors.

Transl Oncol · 2026 · PMC13255033 · PMID 42235210

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did not reach statistical significanceno p-value reported

In addition, immunohistochemical analysis of phosphorylated STING (pSTING) revealed a slight increase in STING activation within tumor tissues from xevinapant-treated mice, particularly in the combination group, although the difference did not reach statistical significance (Supplementary Figure S9A–B).

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highly significantno p-value reported

The increased density of highly significant genes highlights the amplified transcriptional impact of the combination treatment.

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