Resveratrol Alleviates Corticosterone-Induced Hepatic Lipid Metabolism Disorder and Oxidative Stress by Regulating the Nrf2 and AMPK/Sirt1 Signaling Pathways in AA Broilers.

Animals (Basel) · 2026 · PMC13255576 · PMID 42278012

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hedged sentences

0.0100

closest p · 0.2× alpha

0.0500

boldest claim

The sentences

highly significantp < 0.01actually significant

As shown in Table 3 , in broiler livers, the differences in liver function parameters among groups were highly significant ( p < 0.01).

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did not reach statistical significancep > 0.05actually significant

Following cortisol treatment, the mRNA levels of Nrf2 ( p < 0.01), HO-1 ( p < 0.05), and GSH-Px ( p < 0.05) showed a significant downward trend, whilst CAT and SOD also exhibited a downward trend; however, this change did not reach statistical significance ( p > 0.05).

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a decreasing trendno p-value reported

RSV significantly mitigated the CORT-induced increase in SREBP-1 mRNA and protein expression and the decrease in PPARα protein expression; CORT caused a decline in the antioxidant function of AA broiler livers, with significant decreases in SOD and GSH-PX ( p < 0.05), and the expression of Nrf2 and its downstream genes also showed a decreasing trend.

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