Biomarker-Stratified Efficacy of Immune Checkpoint Inhibitors in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis of Randomized Trials.

Cancers (Basel) · 2026 · PMC13255863 · PMID 42279263

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

did not reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

Conversely, in PD-L1-negative cisplatin-eligible patients, ICI use was associated with a numerically worse pooled time-to-event outcomes, which did not reach statistical significance (HR 1.28; 95% CI: 0.99–1.66; p = 0.06, I 2 : 0%) ( Figure 5 C).

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