We observed a borderline significant association for the putative effect of genetically predicted MG liability on AD in the weighted median model (OR = 1.01, 95% CI: 1.00–1.02, p = 0.049) [Supplementary Table S7] , which is not convincing.
Genome-wide analyses indicated modest polygenic overlap between AD and MG, supported by nominally significant and directionally consistent correlations across datasets, SNPeffect concordance in the primary GWAS, and robust gene-level overlap.
In contrast, correlations between MG and its subtypes were strong and highly significant, surpassing multiple-testing thresholds (LOMG vs.