Lung Auscultation for Detecting Interstitial Lung Disease in Patients with Newly Diagnosed Systemic Sclerosis: Retrospective Cohort Study.

Diagnostics (Basel) · 2026 · PMC13256614 · PMID 42279444

Europe PMC DOI

hedged sentences

0.0560

closest p · 1.1× alpha

0.0660

boldest claim

The sentences

showed a trendp < 0.056so close (0.05 < p ≤ 0.1)

In the subset of 49 patients with ILD evaluated by pulmonologists, those who manifested crackles showed a trend toward lower mean % predicted TLC ( p < 0.056) and DLCO ( p < 0.08) compared to those without crackles, but no difference in % predicted FVC ( p < 0.589).

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a trend toward significancep = 0.066so close (0.05 < p ≤ 0.1)

In this multivariable analysis adjusted for age, sex, body mass index, spirometry, and anti-topoisomerase 1 antibody levels, a significant correlation was observed between ILD on HRCT and crackles identified by rheumatologists (IRR 1.643, 95% CI 1.069–2.526, p = 0.024), while crackles detected by pulmonologists showed a trend toward significance (IRR 1.624, 95% CI 0.969–2.721, p = 0.066).

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