Intraperitoneal G-CSF Stimulation Achieves Human-like Neutrophil Levels in NSG Mice Without Inducing Systemic Inflammation.

Three key findings emerged (I) repeated G-CSF dosing induced a substantially stronger and more consistent neutrophil response in the peripheral blood, bone marrow than single-dose regimens, with a numerical trend towards increased neutrophil abundance also observed in the spleen, (II) single-dose administration resulted in only minor or non-significant effects regardless of the dose; and (III) neutrophil expansion occurred without evidence of systemic inflammation, as indicated by stable plasma NE activity and cfDNA levels across all groups. 3.2.

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Although NE activity was numerically higher in all treated groups compared to the controls, these differences did not reach statistical significance ( Figure 4 A).

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