From Pathway Tracing to Actionable Targets: Integrative Mendelian Randomization and Experimental Triangulation Map Metabolic Pathways Across Ovarian Cancer Histotypes.

Despite limited overlap at the single-metabolite level between the two overall OC outcomes, we observed greater concordance at the pathway level: among nominally significant pathways (raw p < 0.05), arginine and proline metabolism and beta-alanine metabolism overlapped across the two outcomes ( Figure 1 E; Supplementary Table S4 ).

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