Targeting Peptidylarginine Deiminases in Neurons and Astrocytes in Central Nervous System Injury-Effects of Pan-PAD Inhibitor Cl-Amidine in an Oxygen-Glucose Deprivation Model of Ischaemia (OGD/R) and LPS Stimulation In Vitro.

Changes in GFAP levels were not statistically significant between treatment groups in the 30 min OGD/R experiment, while there was an observed trend of overall decrease in GFAP-positive staining in the Cl-amidine-treated groups ( Figure 5 (C.1)).

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When assessing S100B-positive staining ( Figure 5 D), Cl-amidine showed a trend (albeit non-significant) of reducing S100B-positive signal in all conditions assessed ( Figure 5 (D.1–D.3)), with significant effects observed in the 1 h OGD/R experiment ( p ≤ 0.05), also in conjunction with LPS stimulation at the lower dose (* p ≤ 0.05) ( Figure 5 (D.2)). 2.6.

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