Redox Imbalance in Gestational Diabetes Mellitus: Mechanistic Insights, Emerging Biomarkers, and Therapeutic Perspectives.

Placental release of 8-Isoprostane is about twice as high in women with GDM compared with women who have healthy pregnancies, with this elevation being highly significant ( p < 0.001).

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Multi-centric randomized trials administering myo-inositol and D-chiro-inositol plus Vitamin D from 12 weeks of gestation demonstrated an improved trend in reducing GDM rates (3.22% in the treatment group versus 5.08% in the vitamin D-alone group), although the difference did not reach statistical significance [ 154 ].

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