Tenecteplase in the Extended 4.5-24-Hour Window for Acute Ischemic Stroke: An Updated Meta-Analysis of RCTs with EVT-Stratified Subgroup Analysis.

Healthcare (Basel) · 2026 · PMC13257171 · PMID 42278723

Europe PMC DOI

hedged sentences

0.0740

closest p · 1.5× alpha

0.1350

boldest claim

The sentences

a nonsignificant trendp = 0.074so close (0.05 < p ≤ 0.1)

Tenecteplase showed a nonsignificant trend toward a higher sICH risk (RR 1.88, 95% CI 0.94–3.78; p = 0.074), with low-to-moderate heterogeneity (I 2 = 24.2%) ( Figure 7 ).

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did not reach statistical significancep = 0.135not close (p > 0.1)

Good functional outcome (mRS 0–2): Analysis of the full cohort showed a numerically higher rate of good functional outcome with tenecteplase that did not reach statistical significance (RR 1.10, 95% CI 0.97–1.24; p = 0.135), with moderate heterogeneity (I-squared = 37.3%, p = 0.172) ( Figure 4 ).

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