Age- and Treatment-Specific TP53 and PI3K Alterations in Pancreatic Ductal Adenocarcinoma (PDAC) Revealed by Conversational Artificial Intelligence.

Int J Mol Sci · 2026 · PMC13257402 · PMID 42278514

Europe PMC DOI

hedged sentences

0.1313

closest p · 2.6× alpha

0.1313

boldest claim

The sentences

highly significantp ≈ 0not a probability at all

Contingency-based statistical testing demonstrated a highly significant enrichment of pathway-level alterations among TP53-mutant tumors ( p ≈ 0), with a strong odds ratio indicating substantial overlap between mutation status and pathway activation.

also in 132,142 other papers

did not reach statistical significancep = 0.1313not close (p > 0.1)

Within early-onset PDAC, TP53 alterations were observed in 80.0% of gemcitabine-treated tumors compared to 40.0% in non-treated tumors, although this difference did not reach statistical significance ( p = 0.1313).

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.