Sacubitril/Valsartan Improves Functional Capacity and Reverses LV Remodeling in Obese Patients with Hypertrophic HFpEF: A Randomized Open-Label Study.

In contrast, in the usual care group, the E/e′ ratio increment during exercise increased slightly from 2.9 to 3.0 ( p = 0.78), resulting in nearly significant between-group differences ( p = 0.053, Table 3 , Figure 4 a).

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