Age-Specific Analysis of the Effects of Intermittent Fasting on Body Composition and Cardiometabolic Markers in Healthy Adults and Individuals with Overweight or Obesity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Nutrients · 2026 · PMC13259446 · PMID 42280443

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hedged sentences

0.0010

closest p · 0.0× alpha

0.0700

boldest claim

The sentences

highly significantp < 0.001actually significant

In the young cohort (<30 years), IF provoked a substantial and highly significant increase in LDL-C (MD = 6.75 mg/dL, 95% CI [3.15, 10.34], p < 0.001, Supplementary Figure S32 ).

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marginally non-significantp = 0.070so close (0.05 < p ≤ 0.1)

Significant reductions in FM were exclusively observed in the young (MD = −1.09 kg, p < 0.001) and older (MD = −1.49 kg, p < 0.001) cohorts, whereas the reduction in early middle-aged adults was marginally non-significant (MD = −1.22 kg, 95% CI [−2.55, 0.10], p = 0.070).

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an adverse trendno p-value reported

More strikingly, our conservative methodological sensitivity analysis (r = 0.5) successfully ‘de-noised’ the pooled data and unmasked a statistically significant increase in LDL-C among middle-aged and older adults as well, an adverse trend that was previously obscured.

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