Modified Guilu Erxian Glue restores immune tolerance in aplastic anemia by reprogramming T cell differentiation via the miR-146a/STAT1/SOCS1 axis.

Front Immunol · 2026 · PMC13259725 · PMID 42292455

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0500

boldest claim

The sentences

highly significantP < 0.01actually significant

MGEG corrects serum cytokine disorder and rebuilds the immune microenvironment Compared to the model group, the MGEG intervention significantly attenuated the aberrantly elevated serum levels of inflammatory markers (TNF-α, IFN-γ, IL-17A) and apoptosis-associated factors (Fas, FasL), with results deemed statistically highly significant ( P < 0.01).

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did not reach statistical significanceP > 0.05actually significant

While the overall recovery trends for RBC and HGB in the MGEG group did not reach statistical significance against the model group ( P > 0.05), the robust efficacy of MGEG in promoting WBC and PLT recovery was statistically comparable to the clinical first-line therapies (IST and IST+EP), with no significant differences observed among these treatment regimens (all P > 0.05) ( Figures 6A–D ).

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