CD14<sup>+</sup>CD16<sup>+</sup> monocyte-derived TREM2 macrophages promote lung fibrosis in systemic sclerosis-interstitial lung disease.

In contrast, although CCL2 levels were elevated in SSc-ILD patients compared with HCs across both CD14 + CD16 - and CD14 + CD16 + macrophage subsets, TREM2 inhibition reduced CCL2 levels, and this decrease did not reach statistical significance ( Supplementary Figure 6 ).

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