Single-nucleus brain transcriptomics reveals microglia dysfunction in multiple system atrophy.

Nat Commun · 2026 · PMC13261106 · PMID 41986335

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To further validate the pool of activated microglia, we cross-referenced them by applying the same markers on an available public dataset containing nuclei from PD patients from the anterior cingulate cortex 45 and observed a nominally significant increased proportion of activated microglia in PD (Supplementary Fig. 15 ), supporting our findings.

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