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Effects of Lysine Deacetylation Inhibition Alone or in Combination With Arimoclomol on TDP-43 Proteinopathy.

J Neurochem · 2026 · PMC13261692 · PMID 42283221

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SAHA increased PPIAK125ac, concomitantly induced nucleus‐cytoplasmic redistribution of PPIA (Figure 2F–H ), along with a reduction in cytoplasmic TDP‐43 and TDP‐35CTF levels, although the latter did not reach statistical significance (Figure 2I,J ).

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